Polyethylene Glycol 3350: Uses, Safety, and What You Need to Know

When you’re dealing with stubborn constipation, Polyethylene Glycol 3350, a non-absorbable osmotic laxative used to draw water into the intestines and soften stool. Also known as PEG 3350, it’s one of the most trusted over-the-counter solutions for occasional bowel issues—used by millions without needing a prescription. Unlike stimulant laxatives that irritate the gut, PEG 3350 works gently by pulling water into the colon, making stools easier to pass. It doesn’t get absorbed into your bloodstream, so it stays in the digestive tract where it’s needed.

This isn’t just a quick fix—it’s a tool used in medical settings too. Doctors often recommend it before colonoscopies because it clears the bowel without causing cramps or electrolyte imbalances. It’s also safe for long-term use in chronic constipation, unlike some other laxatives that can lead to dependency. You’ll find it in brands like MiraLAX, but generic versions work just as well and cost a fraction. It’s often mixed with water or juice, tastes bland, and doesn’t cause bloating for most people. If you’ve tried fiber supplements or stool softeners that didn’t work, PEG 3350 might be the next step.

It’s not for everyone. People with kidney disease, bowel obstructions, or severe nausea should check with a doctor first. Kids and older adults can use it safely, but dosing matters. The standard adult dose is 17 grams daily, dissolved in 8 ounces of liquid. Too much can cause diarrhea, and too little won’t help. It usually takes 1 to 3 days to work, so patience is key. Many users report better results when they pair it with enough water, light movement, and a bit more fiber in their diet.

Related products like lactulose or magnesium citrate work differently—they pull water in too, but can cause gas or cramping. PEG 3350 stands out because it’s predictable, gentle, and rarely causes side effects. It’s also the go-to for people who need regular bowel relief without harsh chemicals. If you’ve ever felt stuck, literally and figuratively, this is one of the few solutions that actually delivers without the drama.

Below, you’ll find real-world advice from people who’ve used it, comparisons with other treatments, and tips to avoid common mistakes. Whether you’re using it for the first time or looking for a better routine, these posts give you the facts without the fluff.